منابع مشابه
Improved Ocular Drug Delivery: A Prodrug Approach
Topical application of eyedrops has been mainly used for treatment of ocular diseases. After instillation of an eyedrop, less than 5% of the applied dose reaches the intraocular tissues. Rapid loss of the instilled solution from the precorneal area and poor cornea1 penetration of the drug results in low ocular bioavailability. However, ocular absorption of a drug can be improved by increasing i...
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The molecular information that became available over the past two decades significantly influenced the field of drug design and delivery at large, and the prodrug approach in particular. While the traditional prodrug approach was aimed at altering various physiochemical parameters, e.g., lipophilicity and charge state, the modern approach to prodrug design considers molecular/cellular factors, ...
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Oligonucleotides (ONs) have been envisaged for therapeutic applications for more than thirty years. However, their broad use requires overcoming several hurdles such as instability in biological fluids, low cell penetration, limited tissue distribution, and off-target effects. With this aim, many chemical modifications have been introduced into ONs definitively as a means of modifying and bette...
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Perispinal injection is a novel emerging method of drug delivery to the central nervous system (CNS). Physiological barriers prevent macromolecules from efficiently penetrating into the CNS after systemic administration. Perispinal injection is designed to use the cerebrospinal venous system (CSVS) to enhance delivery of drugs to the CNS. It delivers a substance into the anatomic area posterior...
متن کاملCurrent approaches to enhance CNS delivery of drugs across the brain barriers
Although many agents have therapeutic potentials for central nervous system (CNS) diseases, few of these agents have been clinically used because of the brain barriers. As the protective barrier of the CNS, the blood-brain barrier and the blood-cerebrospinal fluid barrier maintain the brain microenvironment, neuronal activity, and proper functioning of the CNS. Different strategies for efficien...
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ژورنال
عنوان ژورنال: The AAPS Journal
سال: 2008
ISSN: 1550-7416
DOI: 10.1208/s12248-008-9009-8